diff --git a/CHANGELOG.md b/CHANGELOG.md
index 41e8b9639..0bca536c6 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -9,7 +9,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Added
 
-- Added logging and improved error handling to help diagnose and prevent potential 
+- Added logging and improved error handling to help diagnose and prevent potential
   Pipeline freezes.
 
 - Introduce task watchdog timers. Watchdog timers are used to detect if a
@@ -52,7 +52,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   `LLMAssistantContextAggregator` that exposes whether a function call is in
   progress.
 
-- Added `SambaNovaLLMService` which provides llm api integration with an 
+- Added `SambaNovaLLMService` which provides llm api integration with an
   OpenAI-compatible interface.
 
 - Added `SambaNovaTTSService` which provides speech-to-text functionality using
@@ -84,15 +84,18 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Fixed
 
-- Fixed an issue in `FastAPIWebsocketClient` to ensure proper disconnection 
+- Fixed an issue in `FastAPIWebsocketClient` to ensure proper disconnection
   when the websocket is already closed.
 
 - Fixed an issue where the `UserStoppedSpeakingFrame` was not received if the
   transport was not receiving new audio frames.
 
-- Fixed an edge case where if the user interrupted the bot but no new aggregation 
+- Fixed an edge case where if the user interrupted the bot but no new aggregation
   was received, the bot would not resume speaking.
 
+- Fixed an issue with `TelnyxFrameSerializer` where it would throw an exception
+  when the user hung up the call.
+
 - Fixed an issue with `ElevenLabsTTSService` where the context was not being
   closed.
 
diff --git a/src/pipecat/serializers/telnyx.py b/src/pipecat/serializers/telnyx.py
index 6ef9f7c0d..5f8a09252 100644
--- a/src/pipecat/serializers/telnyx.py
+++ b/src/pipecat/serializers/telnyx.py
@@ -196,8 +196,31 @@ class TelnyxFrameSerializer(FrameSerializer):
                 async with session.post(endpoint, headers=headers) as response:
                     if response.status == 200:
                         logger.info(f"Successfully terminated Telnyx call {call_control_id}")
+                    elif response.status == 422:
+                        # Handle the case where the call has already ended
+                        # Error code 90018: "Call has already ended"
+                        # Source: https://developers.telnyx.com/api/errors/90018
+                        try:
+                            error_data = await response.json()
+                            if any(
+                                error.get("code") == "90018"
+                                for error in error_data.get("errors", [])
+                            ):
+                                logger.debug(
+                                    f"Telnyx call {call_control_id} was already terminated"
+                                )
+                                return
+                        except:
+                            pass  # Fall through to log the raw error
+
+                        # Log other 422 errors
+                        error_text = await response.text()
+                        logger.error(
+                            f"Failed to terminate Telnyx call {call_control_id}: "
+                            f"Status {response.status}, Response: {error_text}"
+                        )
                     else:
-                        # Get the error details for better debugging
+                        # Log other errors
                         error_text = await response.text()
                         logger.error(
                             f"Failed to terminate Telnyx call {call_control_id}: "