diff --git a/.github/workflows/python-compatibility.yaml b/.github/workflows/python-compatibility.yaml
new file mode 100644
index 000000000..243e2c1fa
--- /dev/null
+++ b/.github/workflows/python-compatibility.yaml
@@ -0,0 +1,61 @@
+name: Python Compatibility Test
+
+on:
+  push:
+    branches: [main, develop]
+    paths: ['pyproject.toml']
+  pull_request:
+    branches: [main, develop]
+    paths: ['pyproject.toml']
+
+jobs:
+  test-compatibility:
+    runs-on: ubuntu-latest
+    strategy:
+      fail-fast: false
+      matrix:
+        python-version: ['3.10.18', '3.11.13', '3.12.11', '3.13.5']
+
+    name: Python ${{ matrix.python-version }}
+    steps:
+      - name: Checkout code
+        uses: actions/checkout@v4
+
+      - name: Install system dependencies
+        run: |
+          sudo apt-get update
+          sudo apt-get install -y \
+            portaudio19-dev \
+            libcairo2-dev \
+            libgirepository1.0-dev \
+            pkg-config
+
+      - name: Install uv
+        uses: astral-sh/setup-uv@v4
+        with:
+          version: 'latest'
+
+      - name: Set up Python ${{ matrix.python-version }}
+        run: |
+          uv python install ${{ matrix.python-version }}
+          uv python pin ${{ matrix.python-version }}
+
+      - name: Test uv sync with all extras (Python < 3.13)
+        if: "!startsWith(matrix.python-version, '3.13.')"
+        run: |
+          uv sync --group dev --all-extras --no-extra krisp
+
+      - name: Test uv sync without PyTorch extras (Python 3.13+)
+        if: startsWith(matrix.python-version, '3.13.')
+        run: |
+          uv sync --group dev --all-extras \
+            --no-extra krisp \
+            --no-extra ultravox \
+            --no-extra local-smart-turn \
+            --no-extra moondream \
+            --no-extra mlx-whisper
+
+      - name: Verify installation
+        run: |
+          uv run python --version
+          uv run python -c "import pipecat; print('✅ Pipecat imports successfully')"
diff --git a/pyproject.toml b/pyproject.toml
index 5cf1432d0..3759d7896 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -34,8 +34,6 @@ dependencies = [
     "resampy~=0.4.3",
     "soxr~=0.5.0",
     "openai>=1.74.0,<2",
-    # Explicit dependency pins for Python 3.11+ compatibility
-    "numba>=0.60.0,<1",
 ]
 
 [project.urls]
diff --git a/uv.lock b/uv.lock
index 212d43b0c..a83306cc1 100644
--- a/uv.lock
+++ b/uv.lock
@@ -4029,7 +4029,6 @@ dependencies = [
     { name = "loguru" },
     { name = "markdown" },
     { name = "nltk" },
-    { name = "numba" },
     { name = "numpy" },
     { name = "openai" },
     { name = "pillow" },
@@ -4270,7 +4269,6 @@ requires-dist = [
     { name = "mlx-whisper", marker = "extra == 'mlx-whisper'", specifier = "~=0.4.2" },
     { name = "nltk", specifier = ">=3.9.1,<4" },
     { name = "noisereduce", marker = "extra == 'noisereduce'", specifier = "~=3.0.3" },
-    { name = "numba", specifier = ">=0.60.0,<1" },
     { name = "numpy", specifier = ">=1.26.4,<3" },
     { name = "nvidia-riva-client", marker = "extra == 'riva'", specifier = "~=2.21.1" },
     { name = "onnxruntime", marker = "extra == 'silero'", specifier = "~=1.20.1" },
@@ -4337,7 +4335,7 @@ dev = [
     { name = "pytest", specifier = "~=8.4.1" },
     { name = "pytest-aiohttp", specifier = "==1.1.0" },
     { name = "pytest-asyncio", specifier = "~=1.0.0" },
-    { name = "python-dotenv", specifier = "~=1.1.1" },
+    { name = "python-dotenv", specifier = ">=1.0.1,<2.0.0" },
     { name = "ruff", specifier = "~=0.12.1" },
     { name = "setuptools", specifier = "~=78.1.1" },
     { name = "setuptools-scm", specifier = "~=8.3.1" },